ABSTRACT
The identification of new therapeutic uses for compounds via computational or experimental approaches, which is widely known as drug repurposing, has the potential to develop novel therapies with pre-existing medicines, thereby reducing the time and costs associated with drug development. Today, several data-driven methodologies have been developed leading to databases that facilitate drug repurposing initiatives. However, no approach has systematically compared drug transcriptional profiles to those from a wide spectrum of human diseases or molecular pathways. Here, we present the Drug Repurposing Encyclopedia (DRE, https://www.drugrep.org), an interactive web server covering over 198M significant drug-signature associations across 20 organisms to allow users to carry out drug-repositioning analyses. DRE consists of 12 modules covering real-time drug-repurposing for user-provided transcriptional signatures; gene set enrichment analysis (GSEA) for all available drug transcriptomics profiles; as well as similarity analyses for provided gene sets across all database signatures. Collectively, DRE provides a one-stop comprehensive solution to help scientists interested in drug-repurposing studies.
Competing Interest Statement
The authors have declared no competing interest.