New Results
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, Harley M. Jenks, Esther Morantz, Gloria Larson, Masato Hatta, Jennifer Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashely Burroughs, Terianne Wong, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, View ORCID ProfileAlison S. Laufer Halpin, Laura K. McMullan, Justin S. Lee, Christina F. Spiropoulou, View ORCID ProfileNatalie J. Thornburg, M. Steven Oberste, Vivien Dugan, SSEV Bioinformatics Working Group, David E. Wentworth, View ORCID ProfileBin Zhou
doi: https://doi.org/10.1101/2021.11.24.469906
Li Wang
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Markus H. Kainulainen
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Nannan Jiang
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Han Di
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Gaston Bonenfant
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Lisa Mills
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Michael Currier
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Punya Shrivastava-Ranjan
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Brenda M. Calderon
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Mili Sheth
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Brian R. Mann
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Jaber Hossain
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Xudong Lin
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Sandra Lester
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Elizabeth Pusch
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Joyce Jones
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Dan Cui
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Payel Chatterjee
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Harley M. Jenks
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Esther Morantz
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Gloria Larson
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Masato Hatta
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Jennifer Harcourt
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Azaibi Tamin
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Yan Li
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Ying Tao
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Kun Zhao
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Kristine Lacek
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Ashely Burroughs
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Terianne Wong
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Suxiang Tong
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
John R. Barnes
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Mark W. Tenforde
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Wesley H. Self
2Vanderbilt University, Nashville, Tennessee, USA
Nathan I. Shapiro
3Harvard University, Cambridge, Massachusetts, USA
Matthew C. Exline
4Ohio State University, Columbus, Ohio, USA
D. Clark Files
5Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
Kevin W. Gibbs
5Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
David N. Hager
6Johns Hopkins University, Baltimore, Maryland, USA
Manish Patel
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Alison S. Laufer Halpin
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Laura K. McMullan
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Justin S. Lee
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Christina F. Spiropoulou
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Natalie J. Thornburg
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
M. Steven Oberste
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Vivien Dugan
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
David E. Wentworth
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Bin Zhou
1COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Abstract
The divergence of SARS-CoV-2 into variants of concern/interest (VOC/VOI) necessitated analysis of their impact on vaccines. Escape from vaccine-induced antibodies by SARS-CoV-2 VOC/VOIs was analyzed to ascertain and rank their risk. The variants showed differential reductions in neutralization and replication titers by the post-vaccination sera with Beta variant showing the most neutralization escape that was mechanistically driven by mutations in both the N-terminal domain and receptor-binding domain of the spike.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
Posted November 30, 2021.
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, Harley M. Jenks, Esther Morantz, Gloria Larson, Masato Hatta, Jennifer Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashely Burroughs, Terianne Wong, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, Alison S. Laufer Halpin, Laura K. McMullan, Justin S. Lee, Christina F. Spiropoulou, Natalie J. Thornburg, M. Steven Oberste, Vivien Dugan, SSEV Bioinformatics Working Group, David E. Wentworth, Bin Zhou
bioRxiv 2021.11.24.469906; doi: https://doi.org/10.1101/2021.11.24.469906
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, Harley M. Jenks, Esther Morantz, Gloria Larson, Masato Hatta, Jennifer Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashely Burroughs, Terianne Wong, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, Alison S. Laufer Halpin, Laura K. McMullan, Justin S. Lee, Christina F. Spiropoulou, Natalie J. Thornburg, M. Steven Oberste, Vivien Dugan, SSEV Bioinformatics Working Group, David E. Wentworth, Bin Zhou
bioRxiv 2021.11.24.469906; doi: https://doi.org/10.1101/2021.11.24.469906
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