Abstract
Tigecycline exhibits promising activity against multidrug-resistant gram-negative bacteria (MDR-GNB). However, mobile tigecycline resistance genes, such as tmexCD-toprJ encoding RND efflux pumps, have emerged. Here, we identified a novel tmexC3D2-toprJ3 gene cluster in tigecycline- and carbapenem-nonsusceptible Pseudomonas alcaligenes isolates from hospital sewage in Japan in 2020. tmexC3D2-toprJ3 and two copies of blaIMP-1 were located on the chromosome. This suggests that diverse tmexCD-toprJ-like genes have spread among MDR-GNB worldwide and further epidemiological genomic studies are needed.
Competing Interest Statement
The authors have declared no competing interest.
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