New Results
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann, Georg F. Weber
doi: https://doi.org/10.1101/2020.07.02.184093
Alan Bénard
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Anne Jacobsen
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Maximilian Brunner
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Christian Krautz
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Bettina Klösch
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Izabela Swierzy
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Elisabeth Naschberger
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Torsten Birkholz
2Department of Anesthesiology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Ixchel Castellanos
2Department of Anesthesiology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Denis Trufa
3Department of Thoracic Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Horia Sirbu
3Department of Thoracic Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Marcel Vetter
4Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, German
Andreas E. Kremer
4Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, German
Kai Hildner
4Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, German
Andreas Hecker
5Department of Surgery, University Hospital, Giessen, Germany
Fabian Edinger
5Department of Surgery, University Hospital, Giessen, Germany
Matthias Tenbusch
6Institute of Clinical and Molecular Virology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Enrico Richter
7Institute of Virology, University Hospital, Bonn, Germany
Hendrik Streeck
7Institute of Virology, University Hospital, Bonn, Germany
Marc M. Berger
8Department of Anesthesiology and Intensive CAre Medicine, Essen University Hospital, Essen, Germany
Thorsten Brenner
8Department of Anesthesiology and Intensive CAre Medicine, Essen University Hospital, Essen, Germany
Markus A. Weigand
9Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany
Filip K. Swirski
10Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Georg Schett
11Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Robert Grützmann
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Georg F. Weber
1Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. Here, we report that low plasma interleukin-3 (IL-3) levels were associated with increased severity and mortality during SARS-CoV-2 infections. IL-3 promoted the recruitment of antiviral circulating plasmacytoid dendritic cells (pDCs) into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells. This study identifies IL-3 as a predictive disease marker and potential therapeutic target for SARS-CoV-2 infections.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted July 02, 2020.
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann, Georg F. Weber
bioRxiv 2020.07.02.184093; doi: https://doi.org/10.1101/2020.07.02.184093
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann, Georg F. Weber
bioRxiv 2020.07.02.184093; doi: https://doi.org/10.1101/2020.07.02.184093
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